KLEF has forged robust collaborations through a series of MoUs with diverse organizations, institutions, and industries at both national and international levels, to enhance academic rigor, industry interface, and research opportunities. Internationally, partnerships with Purdue University (USA), the University of North Texas (USA), the University of Malta, the University of Macau (China), and the University of Technology and Applied Sciences (Oman) enable global exposure for students and faculty through exchange programs, collaborative research, and knowledge-sharing initiatives. Industry tie-ups with global giants like Automation Anywhere (USA), Samsung R&D Institute (Bangalore), ServiceNow (USA), and SAS Solutions focus on equipping students with cutting-edge skills and bridging the gap between academia and emerging technologies.
Domestically, KLEF has MoUs with prestigious institutions such as IIT Bombay, IIIT Hyderabad, and NIPER Hyderabad, fostering advanced research and technical training. Collaborations with healthcare organizations like Dr. Ramesh Cardiac and Multispecialty Hospital and AIIMS Mangalagiri provide practical exposure in medical research and community healthcare initiatives. Partnerships with agriculture-focused entities like ICAR, CMFRI Kochi, and Agri Vitro Tech Labs emphasize sustainable agricultural practices and research innovations. Strategic alliances with organizations like Keltron (Kerala), L&T Services (Bangalore), and the National Skill Training Institute aim to enhance industry-relevant skills and promote entrepreneurial growth. These collaborations reflect KLEF's holistic approach to integrating academic excellence with industry and societal needs.
| S. No. | Name of the organization with whom MOU/Collaboration being signed | Date of MoU Signed | Purpose of MOU/Collaboration |
| 1 | Automation Anywhere, USA | 04/04/2019 | Research Prgrams and Activities |
| 2 | Keltron, Kerala | 20/09/2019 | Research Collaboration and faculty exchange |
| 3 | Dr.Ramesh Cardiac and Multispeciality Hospital Pvt Ltd., Vijayawada | 17/12/2019 | Research Training, Student exchange, faculty exchange |
| 4 | Purdue University, USA | 18/06/2019 | Research Collaboration, Student exchange, faculty exchange |
| 5 | Anu Hospital, Vijayawada | 10/12/2019 | Research Training, Student exchange, faculty exchange |
| 6 | LT Services Ltd, Bangalore | 29/03/2019 | Research Prgrams and Activities |
| 7 | Indian Centre For Space Physics (ICSP) | 01/12/2019 | Research Collaboration and faculty exchange |
| 8 | University of North Texas, USA | 28/01/2020 | Research Collaboration, Student exchange, faculty exchange |
| 9 | Samsung R D Institute India - Bangalore Pvt Ltd., Bangalore | 23/12/2020 | Research Prgrams and Activities |
| 10 | SAS Solutions | 22/03/2020 | Research Collaboration and faculty exchange |
| 11 | Test and Verification Solution India Pvt. Ltd., Chennai | 11/12/2021 | Research Collaboration and faculty exchange |
| 12 | Agri Vitro Tech Laboratories, Hyderabad -501401. | 05/07/2021 | Research Collaboration, Student exchange, faculty exchange |
| 13 | Andhra Pradesh State Disaster Management Authority, AP | 02/08/2021 | Research Collaboration, Research Prgrams and Activities |
| 14 | Service Now, USA | 01/03/2021 | Research Collaboration, Research Prgrams and Activities |
| 15 | Indian Council of Agricultural Research (ICAR) | 10/02/2021 | Research Collaboration, Student exchange, faculty exchange |
| 16 | V Care Bio Labs Pvt Ltd, Hyderabad-500090. | 19/07/2021 | Research Collaboration and faculty exchange |
| 17 | Research Lab, Information Technology Department, University of Technology and Applied Sciences, Muscat, Sultanate of Oman | 22/02/2021 | Research Collaboration and faculty exchange |
| 18 | Eesha Communications Systems Pvt. Ltd., Chennai | 28/09/2021 | Research Collaboration, Research Prgrams and Activities |
| 19 | The University of Malta | 04/03/2021 | Research Collaboration, Student exchange, faculty exchange |
| 20 | University of Macau, China | 04/08/2022 | Research Collaboration, Student exchange, faculty exchange |
| 21 | Speech Processing Laboratory, IIIT, Hyderabad | 05/05/2022 | Research Collaboration, faculty exchange |
| 22 | National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad | 09/04/2022 | Research Collaboration, faculty exchange |
| 23 | Prathista industries limited, Hyderabad | 26/09/2022 | Research Prgrams and Activities |
| 24 | Tripura University, Tripura | 26/04/2022 | Research Collaboration, Student exchange, faculty exchange |
| 25 | Tripura Biotech Limited, Hyderabad | 26/09/2022 | Research Collaboration |
| 26 | Indian Institute of Technology Bombay, Mumbai | 17/01/2022 | Research Collaboration and faculty exchange |
| 27 | National Institute of Technical Teachers Training and Research (NITTTR), Chennai | 29/07/2022 | Research Training |
| 28 | Indian Council of Agricultural Research Central Marine Fisheries Research Insitute (CMFRI), Kochi | 28/01/2022 | Research Collaboration |
| 29 | All India Institute of Medical Sciences (AIIMS), Mangalagiri, AP, India | 18/11/2022 | Research Collaboration, Research Prgrams and Activities |
| 30 | National Skill Training Institute | 23/02/2023 | Research Training |